Published February 7, 2008
| Published
Book Section - Chapter
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Label-free single-molecule all-optical sensor
- Other:
- Gannot, Israel
Chicago
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Abstract
Recently, quality factors greater than 100 million were demonstrated using planar arrays of silica microtoroid resonators. These high Q factors allow the toroidal resonators to perform very sensitive detection experiments. By functionalizing the silica surface of the toroid with biotin, the toroidal resonators become both specific and sensitive detectors for Streptavidin. One application of this sensor is performing detection in lysates. To mimic this type of environment, additional solutions of Streptavidin were prepared which also contained high concentrations (nM and μM) of tryptophan.
Additional Information
© 2008 Society of Photo-optical Instrumentation Engineers (SPIE). The authors would like to thank Dr. Rajan Kulkarni for numerous helpful discussions. A.M. Armani is supported by a Clare Boothe Luce Post-doctoral Fellowship. This work was supported by the DARPA Center for OptoFluidic Integration.Attached Files
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Additional details
- Eprint ID
- 90798
- Resolver ID
- CaltechAUTHORS:20181109-123900933
- Clare Boothe Luce Postdoctoral Fellowship
- Defense Advanced Research Projects Agency (DARPA)
- Created
-
2018-11-13Created from EPrint's datestamp field
- Updated
-
2021-11-16Created from EPrint's last_modified field
- Series Name
- Proceedings of SPIE
- Series Volume or Issue Number
- 6852