Published November 1, 2018
| public
Journal Article
Radiosensitization by a Pyrrole-Imidazole Polyamide Through Interference with DNA Repair
Abstract
Non-genotoxic small molecules that potentiate the effects of ionizing radiation in malignant cells could be used to augment radiotherapy for solid tumors. Pyrrole-imidazole (PyeIm) polyamides are synthetic non-genotoxic DNA minor groove-binding small molecules with programmable sequence specificity; binding to DNA induces allosteric changes that can interfere with protein-DNA interactions. We hypothesized that PyeIm polyamides can modulate the cellular response to ionizing radiation.
Additional Information
© 2018 Published by Elsevier Inc. Available online 20 October 2018. Author Disclosure: S. Diaz-Perez: None. N. Kane: None. F. Yang: stock and patents; GeneSciences Inc. A.A. Kurmis: None. N.T. Kummer: None. P.B. Dervan: stock and patents; GeneSciences Inc. N. Nickols: Research Grant; PCF, Bayer. stock, patents; GeneSciences Inc.Additional details
- Eprint ID
- 90335
- DOI
- 10.1016/j.ijrobp.2018.07.604
- Resolver ID
- CaltechAUTHORS:20181022-155441897
- Created
-
2018-10-23Created from EPrint's datestamp field
- Updated
-
2021-11-16Created from EPrint's last_modified field