Increasing heterogeneity in the organization of synaptic inputs of mature olfactory bulb neurons generated in newborn rats
- Creators
- Kelsch, Wolfgang
- Sim, Shuyin
- Lois, Carlos
Abstract
New neurons are added into the mammalian olfactory bulb throughout life, but it remains unknown whether the properties of new neurons generated in newborn animals differ from those added during adulthood. We compared the densities of glutamatergic synapses of granule cells (GCs) generated in newborn and adult rats over extended periods of time. We observed that, whereas adult‐born GCs maintained stable cell‐to‐cell variability of synaptic densities soon after they integrated into the circuit, cell‐to‐cell variability of synaptic densities of neonatal‐born GCs increased months after their integration. We also investigated whether the synaptic reorganization induced by sensory deprivation occurred differently in mature neonatal‐ and adult‐born GCs. Sensory deprivation after new GCs had differentiated induced more pronounced changes in the synaptic densities of neonatal‐born GCs than in adult‐born GCs. These observations suggest that the synapses of mature neonatal‐born GCs retain a higher degree of malleability in response to changes in neuronal activity than adult‐born GCs.
Additional Information
© 2011 Wiley Periodicals, Inc. Issue Online: 07 February 2012; Version of Record online: 07 February 2012; Accepted manuscript online: 18 November 2011; Manuscript accepted: 25 October 2011; Manuscript revised: 29 September 2011; Manuscript received: 20 June 2011. Funding Information: National Institutes of Health (NIH). Grant Number: 5‐R01‐DC008870‐04. Deutsche Forschungsgemeinschaft (DFG). Grant Number: KE1661/1‐1.Additional details
- Eprint ID
- 90218
- Resolver ID
- CaltechAUTHORS:20181009-154457919
- 5-R01-DC008870-04
- NIH
- KE1661/1-1
- Deutsche Forschungsgemeinschaft (DFG)
- Created
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2018-10-10Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field