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Published March 1, 1993 | Published
Journal Article Open

Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia

Abstract

Subventricular zone (SVZ) cells proliferate spontaneously in vivo in the telencephalon of adult mammals. Several studies suggest that SVZ cells do not differentiate after mitosis into neurons or glia but die. In the present work, we show that SVZ cells labeled in the brains of adult mice with [^3H]thymidine differentiate directly into neurons and glia in explant cultures. In vitro labeling with [^3H]thymidine shows that 98% of the neurons that differentiate from the SVZ explants are derived from precursor cells that underwent their last division in vivo. This report identifies the SVZ cells as neuronal precursors in an adult mammalian brain.

Additional Information

© 1993 National Academy of Sciences. Communicated by Fernando Nottebohm, November 19, 1992. We thank P. McLeish for his generous help with culture techniques and F. Nottebohm, John Kim, N. Zarday, S. Ryu, R. Wallen, and K. Yohay for comments on the manuscript. This work was supported by National Institutes of Health Grant NS 28478. C.L. is a Fellow of the La Caixa Foundation graduate program. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.

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