Hard Limits And Performance Tradeoffs In A Class Of Sequestration Feedback Systems
Abstract
Feedback regulation is pervasive in biology at both the organismal and cellular level. In this article, we explore the properties of a particular biomolecular feedback mechanism implemented using the sequestration binding of two molecules. Our work develops an analytic framework for understanding the hard limits, performance tradeoffs, and architectural properties of this simple model of biological feedback control. Using tools from control theory, we show that there are simple parametric relationships that determine both the stability and the performance of these systems in terms of speed, robustness, steady-state error, and leakiness. These findings yield a holistic understanding of the behavior of sequestration feedback and contribute to a more general theory of biological control systems.
Additional Information
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license. The authors would like to thank Reed McCardell for providing insight into the synthetic growth circuit, and Hana El-Samad for providing feedback on the manuscript. The project was sponsored by the Defense Advanced Research Projects Agency (Agreement HR0011-17-2-0008). The content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred. Author Contributions: Conceptualization and Methodology, NO, AAB, FX, YPL, JCD, and RMM; Formal Analysis, NO, AAB, FX, and YPL; Software, NO, AAB, and YPL; Writing, NO, AAB, and FX; Supervision and Funding, JCD and RMM. The authors declare no competing interests.Attached Files
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Additional details
- Eprint ID
- 90015
- Resolver ID
- CaltechAUTHORS:20180927-114225422
- HR0011-17-2-0008
- Defense Advanced Research Projects Agency (DARPA)
- Created
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2018-09-27Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field