Three-dimensional photoacoustic tomography based on the focal-line concept

Creators: Xia, Jun; Guo, Zijian; Maslov, Konstantin; Aguirre, Andres; Zhu, Quing; Percival, Christopher; Wang, Lihong V.

Abstract

A full ring ultrasonic array-based photoacoustic tomography system was recently developed for small animal brain imaging. The 512-element array is cylindrically focused in the elevational direction, and can acquire a two-dimensional (2D) image in 1.6 s. In this letter, we demonstrate the three-dimensional (3D) imaging capability of this system. A novel 3D reconstruction algorithm was developed based on the focal-line concept. Compared to 3D images acquired simply by stacking a series of 2D images, the 3D focal-line reconstruction method renders images with much less artifacts, and improves the elevational resolution by 30% and the signal-to-noise ratio by two times. The effectiveness of the proposed algorithm was first validated by numerical simulations and then demonstrated with a hair phantom experiment and an ex vivo mouse embryo experiment.

Additional Information

© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). Paper 11172LRR received Apr. 11, 2011; revised manuscript received Jul. 21, 2011; accepted for publication Jul. 26, 2011; published online Sep. 2, 2011. The authors would like to thank Dr. Richtsmeier for support on the embryos. This work was sponsored in part by National Institutes of Health Grant Nos. R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 EB010049, 5P60 DK02057933 (L.W.), and R01 DE018500, and National Science Foundation Grant No. BCS 0725227 (C.P.). L.W. has a financial interest in Microphotoacoustics, Inc., and Endra, Inc., which, however, did not support this work.

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