Optical coherence computed tomography

Abstract

We proposed a novel time-resolved optical tomography, optical coherence computed tomography. It married the key concepts of time-resolved diffuse optical tomography and optical coherence tomography. Both ballistic and multiple-scattered photons were measured at multiple source-detection positions by low-coherence interferometry. It measures the reemitted light with a temporal resolution of 56 femtoseconds, which is much better than the resolution of conventional time-resolved detection systems. A light-tissue interaction model was established using the time-resolved Monte Carlo method. The optical properties were then reconstructed by solving the inverse time-resolved radiative transport problem under the first Born approximation. Our initial results showed the potential of this technology to bridge the gap between diffuse optical tomography and optical coherence tomography.

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