Published October 2011
| Published
Journal Article
Open
Functional photoacoustic microscopy of pH
Chicago
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Abstract
pH is a tightly regulated indicator of metabolic activity. In mammalian systems, an imbalance of pH regulation may result from or result in serious illness. In this paper, we report photoacoustic microscopy (PAM) of a commercially available pH-sensitive fluorescent dye (SNARF-5F carboxylic acid) in tissue phantoms. We demonstrated that PAM is capable of pH imaging in absolute values at tissue depths of up to 2.0 mm, greater than possible with other forms of optical microscopy.
Additional Information
© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). Paper 11186LRR received Apr. 12, 2011; revised manuscript received Aug. 24, 2011; accepted for publication Sep. 9, 2011; published online Oct. 14, 2011. The authors thank James Ballard and Sandra Matteucci for help in manuscript edition. This work was supported in part by National Institutes of Health Grant Nos. U54CA136398 and R01 EB000712. L. V. Wang has a financial interest in Microphotoacoustics, Inc. and Endra, Inc, which, however, did not support this work.Attached Files
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Additional details
- PMCID
- PMC3210191
- Eprint ID
- 89749
- Resolver ID
- CaltechAUTHORS:20180918-140711597
- NIH
- U54 CA136398
- NIH
- R01 EB000712
- Created
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2018-09-18Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field