Published May 2, 1995
| public
Journal Article
Metal-Induced Dispersion of Lipid Aggregates: A Simple, Selective, and Sensitive Fluorescent Metal Ion Sensor
Abstract
A new metal ion sensor capable of detecting nanomolar concentrations (< 1 ppb) of Cu^(2+) is made from mixed vesicles of a novel pyrene‐labeled metal‐chelating ligand and distearoyl phosphatidylcholine. When copper is added, the fluorescence monomer intensity emitted at 377 nm greatly increases, while the intensity of light emitted at 470 nm decreases. This effect is probably due to the dispersal of the fluorescent lipid throughout the matrix upon metal binding and is depicted schematically below.
Additional Information
© 1995 by VCH Verlagsgesellschaft mbH. Manuscript received: 13 October 1994. Manuscript revised: 06 December 1994. This research was supported by the Office of Naval Research (N00014‐92‐J‐1178) and the National Science Foundation (BCS‐9108502). F. H. A. acknowledges an NSF PYI Award and a David and Lucile Packard Fellowship. D. R. S. is supported by a predoctoral training fellowship from the National Institute of General Medical Sciences. Pharmacology Sciences Program. D. W. P. is a Landau Fellow.Additional details
- Eprint ID
- 89110
- Resolver ID
- CaltechAUTHORS:20180823-144311536
- N00014‐92‐J‐1178
- Office of Naval Research (ONR)
- BCS‐9108502
- NSF
- David and Lucile Packard Foundation
- NIH Predoctoral Fellowship
- Landau fellowship
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2018-08-23Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field