Chemistry and biology of asparagine-linked glycosylation
Abstract
The biosynthesis of glycoprotein conjugates is a complex process that involves the collective action of numerous enzymes. Recent research on the chemistry and biology of asparagine-linked glycosylation in our group has been focused on two specific areas. These are the development of potent inhibitors of oligosaccharyl transferase and the investigation of the conformational consequences of the glycosylation process. Since asparagine-linked glycosylation is an essential eukaryotic process, an understanding of the details of this complex transformation is of utmost importance both to fundamental biochemistry and to a consideration of the mechanisms of homeostatic control.
Additional Information
© 1999 IUPAC. This research was supported by the National Institutes of Health (GM 39334).Attached Files
Published - _Pure_and_Applied_Chemistry__Chemistry_and_biology_of_asparagine-linked_glycosylation.pdf
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Additional details
- Eprint ID
- 88720
- Resolver ID
- CaltechAUTHORS:20180809-152106445
- GM 39334
- NIH
- Created
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2018-08-09Created from EPrint's datestamp field
- Updated
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2023-03-16Created from EPrint's last_modified field