N-Terminal Sequence of Human Big Gastrin: Sequence, Synthetic and Immunochemical Studies

Creators: Choudhury, Abdul M.; Kenner, George W.; Moore, Stanley; Ramachandran, Kuzhalmannan L.; Thorpe, Warwick D.; Ramage, Robert; Dockray, Graham J.; Gregory, Roderic A.; Hood, Leroy; Hunkapiller, Michael

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Abstract

The previously assigned structure of human big gastrin is revised as a result of sequencing and immunological studies on synthetic peptides. A nonadecapeptide has been synthesized and found to have full immunochemical potency compared with natural human G34 in a radioimmunossay which is specific for the N-terminal sequence.

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Resource type: Journal Article
Publisher: De Gruyter
Published in: Biological Chemistry, 361(2), 1719-1734, ISSN: 1431-6730.

Created:: August 19, 2023
Modified:: October 18, 2023