Improved in vivo imaging of human blood circulation in the chorioretinal complex using phase variance method with new phase stabilized 1 μm swept-source optical coherence tomography (pv-SSOCT)
Abstract
We demonstrate the feasibility of our newly developed phase stabilized high-speed (100 kHz A-scans/s) 1 μm sweptsource optical coherence tomography (SSOCT) system with the phase-variance based motion contrast method for visualization of human chorioretinal complex microcirculation. Compared to our previously reported spectral domain (spectrometer based) phase-variance (pv)-SDOCT system it has advantages of higher sensitivity, reduced fringe washout for high blood flow speeds and deeper penetration in choroid. High phase stability SSOCT imaging was achieved by using a computationally efficient phase stabilization approach. This process does not require additional calibration hardware and complex numerical procedures. Our phase stabilization method is simple and can be employed in a variety of SS-OCT systems. Examples of vasculature in the chorioretinal complex imaged by pv-SSOCT is presented and compared to retinal images of the same volunteers acquired with fluorescein angiography (FA) and indocyanine green angiography (ICGA).
Additional Information
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE). We gratefully acknowledge the contributions of VSRI UC Davis lab members and the Biological Imaging Center at the California Institute of Technology for supporting the phase-variance post-processing software. This research was supported by the National Eye Institute (EY 014743) and Research to Prevent Blindness (RPB).Attached Files
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Additional details
- Eprint ID
- 87825
- Resolver ID
- CaltechAUTHORS:20180713-111318398
- EY 014743
- NIH
- Research to Prevent Blindness
- Created
-
2018-07-16Created from EPrint's datestamp field
- Updated
-
2021-11-15Created from EPrint's last_modified field
- Series Name
- Proceedings of SPIE
- Series Volume or Issue Number
- 8930