Redox Sensitive Metastable DNA Junctions for Multivalent Delivery of Therapeutics

Abstract

Delivery is one of the most challenging technical barriers for effective use of oligonucleotide therapeutics (OT) in vivo. Recent studies have demonstrated that simple nucleic acid nanostructures can act as molecularly uniform, multivalent carrier platforms for therapeutic cargos and cell targeting ligands. Although this approach has significant promise, much remains unknown regarding the effects of carrier nanostructures on the (I) in vivo distribution and pharmacokinetics, (II) cell entry and endosomal escape and (III) cytoplasmic processing of therapeutic cargos such as small interfering RNAs (siRNA).

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