Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published March 26, 1997 | public
Journal Article

DNA-Photocleavage Activities of Vanadium(V)−Peroxo Complexes

Abstract

The DNA-photocleavage activities (at 365 nm) of 15 vanadium(V)−peroxo complexes were examined. Singlet oxygen was implicated as the species responsible for the DNA scission. The singlet oxygen was shown to be produced from the photolysis of the vanadium(V)−peroxo complex using a singlet oxygen EPR spin trap, 2,2,6,6-tetramethyl-4-piperidone. A mechanism for the photolysis of the [VO(O_2)_2(bpy)]- anion at neutral pH has been proposed.

Additional Information

© 1997 American Chemical Society. Received August 1, 1996. We gratefully acknowledge the financial support of the Hong Kong Baptist University Faculty Research Grants (FRG/93-94/II-68; to D.W.J.K.), the Hong Kong Research Grants Council (HKBC 153/95P; to D.W.J.K.), and the National Institute of General Medical Sciences, U.S. Public Health Service (GM22432; to S.I.C.). S.M.M. is a recipient of a National Research Service Predoctoral Award from the National Institute of General Medical Services.

Additional details

Created:
August 19, 2023
Modified:
October 18, 2023