Published April 7, 1993
| Supplemental Material
Journal Article
Open
NMR evidence for specific intercalation of Δ-rh(phen)_2phi^(3+) in [d(GTCGAC)_2]
- Creators
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David, Sheila S.
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Barton, Jacqueline K.
Chicago
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Abstract
The anchoring of metal complexes in the major groove of DNA through intercalation has been increasingly useful in the shape-selective design of novel metal complexes which bind DNA with high sequence-selectivity. Toward that goal, direct structural information regarding this intercalative interaction is essential. Phenanthrenequinone diimine (phi) complexes of Rh(III) bind avidly (K_b 1 ≥ 10^7) to DNA by intercalation in the major groove. Here we report the first ^1H-NMR studies of Δ-rh(phen)_2phi^(3+) bound to an oligonucleotide. These studies provide direct structural evidence for specific intercalation by this octahedral complex in the major groove of DNA.
Additional Information
© 1993 American Chemical Society. Received December 15. 1992. We are grateful to the National Institutes of Health (GM33309 and an NRSA GM13861-03 to S.S.D.) for their financial support. In addition, we thank B. Imperiali for help in processing the NMR data.Attached Files
Supplemental Material - ja00060a060_si_001.pdf
Supplemental Material - ja2984.pdf
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ja00060a060_si_001.pdf
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Additional details
- Alternative title
- NMR evidence for specific intercalation of .DELTA.-rh(phen)2.phi.3+ in [d(GTCGAC)2]
- Eprint ID
- 86175
- Resolver ID
- CaltechAUTHORS:20180501-151531707
- NIH
- GM33309
- NIH Predoctoral Fellowship
- GM13861-03
- Created
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2018-05-02Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field