Effect of optical aberrations on intraocular pressure measurements using a microscale optical implant in ex vivo rabbit eyes
Abstract
Elevated intraocular pressure (IOP) is the only modifiable major risk factor of glaucoma. Recently, accurate and continuous IOP monitoring has been demonstrated in vivo using an implantable sensor based on optical resonance with remote optical readout to improve patient outcomes. Here, we investigate the relationship between optical aberrations of ex vivo rabbit eyes and the performance of the IOP sensor using a custom-built setup integrated with a Shack–Hartmann sensor. The sensor readouts became less accurate as the aberrations increased in magnitude, but they remained within the clinically acceptable range. For root-mean-square wavefront errors of 0.10 to 0.94 μm, the accuracy and the signal-to-noise ratio were 0.58 ± 0.32 mm Hg and 15.57 ± 4.85 dB, respectively.
Additional Information
© 2018 The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. Paper 180037R received Jan. 18, 2018; accepted for publication Mar. 23, 2018; published online Apr. 12, 2018. This work was supported by the National Institutes of Health (No. EY024582) and the Heritage Medical Research Institute. The authors declare that there are no conflicts of interest related to this article. All ex vivo experiments were performed using the rabbit eyes enucleated in a FACTA Humane Certified facility (Pel-Freeze).Attached Files
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Additional details
- Eprint ID
- 85882
- Resolver ID
- CaltechAUTHORS:20180416-143006166
- EY024582
- NIH
- Heritage Medical Research Institute
- Created
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2018-04-16Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field
- Caltech groups
- Heritage Medical Research Institute