Published June 1, 2018
| Accepted Version
Journal Article
Open
Enantioselective palladium-catalyzed allylic alkylation reactions in the synthesis of Aspidosperma and structurally related monoterpene indole alkaloids
- Creators
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Pritchett, Beau P.
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Stoltz, Brian M.
Abstract
Enantioselective Pd-catalyzed allylic alkylations of prochiral enolates represent a powerful tool for the construction of all-carbon quaternary stereocenters. This review describes the emergence of such reactions as strategic linchpins that enable efficient, stereocontrolled syntheses of Aspidosperma and related monoterpene indole alkaloids.
Additional Information
© 2018 The Royal Society of Chemistry. The article was received on 23 Dec 2017 and first published on 16 Apr 2018. The authors wish to thank NIH-NIGMS (R01GM080269), Amgen, the Gordon and Betty Moore Foundation, and Caltech for financial support. B. P. P. thanks the NSF for a predoctoral fellowship (Grant DGE-1144469). Dr Robert Allen Craig, II, is thanked for editorial assistance. The authors declare no conflicts of interest.Attached Files
Accepted Version - nihms961707.pdf
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nihms961707.pdf
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Additional details
- PMCID
- PMC6013405
- Eprint ID
- 85877
- DOI
- 10.1039/c7np00069c
- Resolver ID
- CaltechAUTHORS:20180416-135313177
- R01GM080269
- NIH
- Amgen
- Gordon and Betty Moore Foundation
- Caltech
- DGE-1144469
- NSF Graduate Research Fellowship
- Created
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2018-04-16Created from EPrint's datestamp field
- Updated
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2022-03-09Created from EPrint's last_modified field