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Published July 1, 2011 | public
Journal Article

Response to Comment on "The Mechanism for Activation of GTP Hydrolysis on the Ribosome"

Abstract

Our report of the crystal structure of elongation factor Tu (EF-Tu) and aminoacyl–transfer RNA bound to the ribosome with a guanosine triphosphate (GTP) analog included a proposed mechanism of GTP hydrolysis by EF-Tu involving histidine-84. Liljas et al. summarize experimental evidence against this mechanism and propose a substrate-assisted catalytic model. However, these experiments and the model are also problematic. Further study is required to definitively determine the mechanism of GTP hydrolysis by EF-Tu.

Additional Information

© 2011 American Association for the Advancement of Science. Received 28 January 2011; accepted 1 June 2011.

Additional details

Created:
August 19, 2023
Modified:
October 18, 2023