Hopanoid lipids: from membranes to plant–bacteria interactions
Abstract
Lipid research represents a frontier for microbiology, as showcased by hopanoid lipids. Hopanoids, which resemble sterols and are found in the membranes of diverse bacteria, have left an extensive molecular fossil record. They were first discovered by petroleum geologists. Today, hopanoid-producing bacteria remain abundant in various ecosystems, such as the rhizosphere. Recently, great progress has been made in our understanding of hopanoid biosynthesis, facilitated in part by technical advances in lipid identification and quantification. A variety of genetically tractable, hopanoid-producing bacteria have been cultured, and tools to manipulate hopanoid biosynthesis and detect hopanoids are improving. However, we still have much to learn regarding how hopanoid production is regulated, how hopanoids act biophysically and biochemically, and how their production affects bacterial interactions with other organisms, such as plants. The study of hopanoids thus offers rich opportunities for discovery.
Additional Information
© 2018 Macmillan Publishers Limited, part of Springer Nature. Published online: 19 February 2018. The authors thank A. Session, P. Normand and the reviewers for constructive comments on the manuscript. We appreciate permission from D. Benson, A. Berry and J. Sáenz to reproduce images from their work. Grants from the Howard Hughes Medical Institute (HHMI; D.K.N.), National Aeronautics and Space Administration (NASA; NNX12AD93G, D.K.N.), the Jane Coffin Childs Memorial Fund (B.J.B.), the US National Institutes of Health (NIH; K99GM126141, B.J.B.), H2020- MSCA-ITN-2014-ETN TOLLerant (A.S.), Progetto Galileo G14-23 (A.S.), Mizutani Foundation for Glycoscience 2014 (A.M.) and the French National Research Agency (ANR-BugsInaCell-13-BSV7-0013) have sustained our research on this problem. Author Contributions: B.J.B, E.G., A.S. and D.K.N. researched data for the article. B.J.B., E.G., A.M., A.S. and D.K.N. substantially contributed to the discussion of content. B.J.B., N.B., E.G., A.S. and D.K.N. wrote the article. All authors reviewed and edited the manuscript before submission. The authors declare no competing financial interests.Attached Files
Accepted Version - nihms-983957.pdf
Files
Name | Size | Download all |
---|---|---|
md5:8d5ca136d470a5423e6be5a781c5e92d
|
1.1 MB | Preview Download |
Additional details
- PMCID
- PMC6087623
- Eprint ID
- 84914
- Resolver ID
- CaltechAUTHORS:20180221-160552040
- Howard Hughes Medical Institute (HHMI)
- NNX12AD93G
- NASA
- Jane Coffin Childs Memorial Fund
- K99GM126141
- NIH
- H2020-MSCA-ITN-2014-ETN TOLLerant
- European Research Council (ERC)
- G14-23
- Progetto Galileo
- Mizutani Foundation for Glycoscience
- ANR-BugsInaCell-13-BSV7-0013
- Agence Nationale pour la Recherche (ANR)
- Created
-
2018-02-22Created from EPrint's datestamp field
- Updated
-
2021-11-15Created from EPrint's last_modified field
- Caltech groups
- Division of Geological and Planetary Sciences