Bone CLARITY reveals that anti-sclerostin antibody penetrates the lacunar canalicular system in mice under physiological loading conditions

Creators: Greenbaum, Alon; Chan, Ken; Boyce, Rogely; Salimi-Moosavi, Hossein; McBride, Helen J.; Gradinaru, Viviana

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Abstract

Anti-sclerostin antibody (Scl-Ab) neutralizes sclerostin activity, a secreted protein from osteocytes, resulting in WNT mediated increases in bone formation and decreases in bone resorption; this dual effect on bone results in rapid increases in bone mass and strength.

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Resource type: Journal Article
Publisher: Wiley
Published in: Journal of Bone and Mineral Research, 32(S1), S293, ISSN: 0884-0431.
Conference: 2017 Annual Meeting of the American Society for Bone and Mineral Research , Denver, CO, September 8-11, 2017

Created:: August 19, 2023
Modified:: October 18, 2023