Total synthesis and study of myrmicarin alkaloids

Abstract

A convergent total synthesis of myrmicarin alkaloids and related derivatives based on a potentially biomimetic dimerization of optically active pyrroloindolizines is described. A variety of dimerization strategies are discussed that take advantage of the unique chemistry of pyrroloindolizines. Mechanistic insights regarding the high level of substrate directed stereoselection in these dimerization reactions will be discussed.

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