Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids

Creators: Gao, Wei^{1, 2}; Nyein, Hnin Y. Y.^{1, 2}; Shahpar, Ziba¹; Fahad, Hossain M.¹; Chen, Kevin^{1, 2}; Emaminejad, Sam^{1, 2}; Gao, Yuji^{1, 2}; Tai, Li-Chia^{1, 2}; Ota, Hiroki^{1, 2}; Wu, Eric¹; Bullock, James^{1, 2}; Zeng, Yuping¹; Lien, Der-Hsien^{1, 2}; Javey, Ali^{1, 2}

1. University of California, Berkeley
2. Lawrence Berkeley National Laboratory

Style

An error occurred while generating the citation.

Abstract

A flexible and wearable microsensor array is described for simultaneous multiplexed monitoring of heavy metals in human body fluids. Zn, Cd, Pb, Cu, and Hg ions are chosen as target analytes for detection via electrochemical square wave anodic stripping voltammetry (SWASV) on Au and Bi microelectrodes. The oxidation peaks of these metals are calibrated and compensated by incorporating a skin temperature sensor. High selectivity, repeatability, and flexibility of the sensor arrays are presented. Human sweat and urine samples are collected for heavy metal analysis, and measured results from the microsensors are validated through inductively coupled plasma mass spectrometry (ICP-MS). Real-time on-body evaluation of heavy metal (e.g., zinc and copper) levels in sweat of human subjects by cycling is performed to examine the change in concentrations with time. This platform is anticipated to provide insightful information about an individual's health state such as heavy metal exposure and aid the related clinical investigations.

Additional Information

© 2016 American Chemical Society. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes. Received 26 April 2016. Date accepted 9 May 2016. Published online 9 May 2016. Published in print 22 July 2016. This work was supported by NSF Nanomanufacturing Systems for Mobile Computing and Energy Technologies (NASCENT) Center. The sensor fabrication was performed in the Electronic Materials (E-MAT) laboratory funded by the Director, Office of Science, Office of Basic Energy Sciences, Material Sciences and Engineering Division of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. K.C. acknowledges support from the Robert N. Noyce Fellowship in Microelectronics. H.O. acknowledges support from the Japan Society for the Promotion of Science (JSPS) Fellowship.

Attached Files

Published - acssensors.6b00287.pdf

Supplemental Material - se6b00287_si_001.pdf

Files

se6b00287_si_001.pdf

Files (7.3 MB)

Name	Size	Download all
se6b00287_si_001.pdf md5:b0bb80769783928e1b8aa44e2051aff5	623.1 kB	Preview Download
acssensors.6b00287.pdf md5:ed759fb170a5743e4976ffb8f0940044	6.7 MB	Preview Download

Additional details

	All versions	This version
Views	27	27
Downloads	24	24
Data volume	107.0 MB	107.0 MB