Published May 28, 1996
| public
Journal Article
DNA Cleavage by an α,3-Dehydrotoluene Precursor Conjugated to a Minor Groove Binding Element
- Creators
- Myers, Andrew G.
- Parrish, Cynthia A.
Chicago
An error occurred while generating the citation.
Abstract
The (Z)-allene-ene-yne 10, a precursor to a reactive α,3-dehydrotoluene biradical, was covalently linked to a minor groove binding element, and the resultant conjugate (9) was shown to bind and cleave DNA with sequence selectivity.
Additional Information
© 1996 American Chemical Society. Received November 21, 1995. Publication Date (Web): May 28, 1996. Generous support from the National Institutes of Health is gratefully acknowledged. C.A.P. acknowledges support from NIH Training Grant T32GM08501. We also thank Professor Peter B. Dervan and his research group, with special thanks to Dr. Milan Mrksich, for their many helpful suggestions throughout the course of this work.Additional details
- Eprint ID
- 81573
- Resolver ID
- CaltechAUTHORS:20170919-134911678
- NIH Predoctoral Fellowship
- T32GM08501
- Created
-
2017-09-19Created from EPrint's datestamp field
- Updated
-
2021-11-15Created from EPrint's last_modified field
- Other Numbering System Name
- Caltech Arnold and Mabel Beckman Laboratories of Chemical Synthesis
- Other Numbering System Identifier
- 9103