Building bridges: Strategies and tactics for the synthesis of polycyclic natural products

Abstract

The chem. synthesis of natural products provides an exciting platform from which to conduct fundamental research in chem. and biol. An area of ongoing research in our lab. is the synthesis of polyhydroxylated diterpenoids, such as ryanodol and ryanodine, as well as several members of the diterpenoid alkaloids. The densely-packed arrays of heteroatoms and stereogenic centers that constitute these polycyclic targets challenge the limits of current technol. and inspire the development of new synthetic strategies and tactics. This seminar will describe our latest progress in our target directed synthesis endeavors.

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