Published July 13, 2000
| public
Journal Article
Stereoselectivity of Macrocyclic Ring-Closing Olefin Metathesis
- Creators
- Lee, Choon Woo
-
Grubbs, Robert H.
Chicago
An error occurred while generating the citation.
Abstract
Macrocyclic ring-closing olefin metathesis using ruthenium catalyst 3 was performed to produce a 14-membered lactone. The E/Z ratio of lactone was high regardless of the R group (auxiliary) or the initial alkene stereochemistry. A kinetic study demonstrates that the high E/Z ratio is due to secondary metathesis reactions that isomerize the product to the thermodynamic E/Z ratio.
Additional Information
© 2000 American Chemical Society. Received May 13, 2000. Publication Date (Web): June 17, 2000. Support has been generously provided by the National Institute of Health. C.W.L. acknowledges the Korea Science and Engineering Foundation (KOSEF) for a postdoctoral fellowship. The authors thank Christopher W. Bielawski, John P. Morgan, Dr. Michael Ulman, and Dr. Hyunjin Kim for useful discussions. Matthias Scholl and Melanie S. Sanford are acknowledged for the generous supply of catalyst 3.Additional details
- Eprint ID
- 79881
- Resolver ID
- CaltechAUTHORS:20170807-160413253
- NIH
- Korea Science and Engineering Foundation
- Created
-
2017-08-07Created from EPrint's datestamp field
- Updated
-
2021-11-15Created from EPrint's last_modified field