Easily fabricated ion source for characterizing mixtures of organic compounds by direct analysis in real time mass spectrometry
Abstract
The increasing use of atmospheric pressure mass spectrometry has led to the development of many ambient ionization sources, for which sampling versatility and low cost are desired features. One such recent ambient ionization method is direct analysis in real time mass spectrometry (DART-MS), which has proven to be well suited to the analysis of native samples of both simple and complex natures. We describe a home-built DART source (EZ-DART) with versatile sampling capabilities, low power requirements, and low assembly cost which can be easily interfaced to mass spectrometers equipped with an atmospheric pressure inlet. The operating temperature range (22–250 °C) enables the acquisition of both temperature programmed desorption-based DART mass spectra and the collection of multistep collision-induced dissociation (CID) mass spectra. We present here the validation of the EZ-DART source and a demonstration of its performance in a number of relevant applications. Additionally, we introduce the new DART application of reagent assisted desorption ionization (RADI) for the targeting of specific chemical functionality in complex organic mixtures through a host–guest chemical system.
Additional Information
© 2017 The Royal Society of Chemistry. The article was received on 13 Apr 2017, accepted on 20 Jul 2017 and first published on 21 Jul 2017. The research was funded by NSF award number CHE-1508825. The early part of this work was funded by NASA Astrobiology Institute, Titan as a Prebiotic Chemical System and the Keck Institute for Space Studies, Future Missions to Titan: Scientific and Engineering Challenges. K. T. U. acknowledges financial support from the Harriett Jenkins Pre-Doctoral Fellowship Program. The authors would like to thank Mike Uribe Productions for the EZ-DART photographs and the Caltech Glass Shop for assistance with manufacture of the EZ-DART source. There are no conflicts of interest to declare.Attached Files
Supplemental Material - c7ay00971b1_si.pdf
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Additional details
- Eprint ID
- 79667
- Resolver ID
- CaltechAUTHORS:20170801-093347646
- NSF
- CHE-1508825
- NASA Predoctoral Fellowship
- Keck Institute for Space Studies (KISS)
- Created
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2017-08-01Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field
- Caltech groups
- Keck Institute for Space Studies