Surfactant Activated Dip-Pen Nanolithography
Abstract
Direct nanoscale patterning of maleimide-linked biotin on mercaptosilane-functionalized glass substrates using dip-pen nanolithography (DPN) was facilitated by the addition of a small amount of the biocompatible nonionic surfactant Tween-20. A correlation was found between activated biotin transfer from the AFM tip with surfactant included in the ink and an increase in the wettability of the partially hydrophobic silanized substrate. Surfactant concentration represents a new control variable for DPN that complements relative humidity, tip−substrate contact force, scan speed, and temperature. Using surfactants systematically as ink additives may expand the possible ink−substrate combinations that can be used for patterning biotin and other biomolecules, including proteins.
Additional Information
© 2004 American Chemical Society. Received 10 August 2004; Published online 2 October 2004; Published in print 1 November 2004. The authors thank Prof. Jim Heath (Caltech) for use of the contact angle goniometer, and Dr. Lorenzo Busoni and Prof. Marcello Carlà (University of Florence) for help with the axisymmetric drop shape analysis program. R.S. acknowledges support from the Student-Faculty Programs Office at Caltech and the Arthur Amos Noyes SURF Endowment for a summer undergraduate research fellowship. This work was supported by Caltech startup funds and by Arrowhead Research.Attached Files
Supplemental Material - nl048705csi20040927_044734.pdf
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Additional details
- Eprint ID
- 79581
- DOI
- 10.1021/nl048705c
- Resolver ID
- CaltechAUTHORS:20170731-090555460
- Caltech
- Arrowhead Research
- Created
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2017-08-01Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field