Published December 15, 2017
| Submitted + Supplemental Material
Journal Article
Open
Enzyme-Free Nucleic Acid Dynamical Systems
Chicago
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Abstract
An important goal of synthetic biology is to create biochemical control systems with the desired characteristics from scratch. Srinivas et al. describe the creation of a biochemical oscillator that requires no enzymes or evolved components, but rather is implemented through DNA molecules designed to function in strand displacement cascades. Furthermore, they created a compiler that could translate a formal chemical reaction network into the necessary DNA sequences that could function together to provide a specified dynamic behavior.
Additional Information
© 2017 American Association for the Advancement of Science. Received 25 October 2016; accepted 25 October 2017. We thank L. Qian for help with initial experiments and technical training; C. G. Evans for supporting the development of Piperine; A. Phillips for assistance with Visual DSD; and L. Cardelli, C. Geary, C. T. Martin, N. A. Pierce, P. W. K. Rothemund, S. L. Sparvath, B. Wolfe, F. Dannenberg, and D. Y. Zhang for helpful discussions. This work was supported by the NSF grants 0728703, 0829805, 0832824, 1317694, 1117143, and 1618895; Office of Naval Research award N00014-16-1-2139; the Gordon and Betty Moore Foundation's Programmable Molecular Technology Initiative; and National Institute of General Medical Sciences Systems Biology Center grant P50 GM081879. Data presented in the paper are archived in the Supplementary Materials.Attached Files
Submitted - 138420.full.pdf
Supplemental Material - 138420-1.pdf
Supplemental Material - aal2052_Srinivas_SM.pdf
Files
aal2052_Srinivas_SM.pdf
Additional details
- Eprint ID
- 79580
- Resolver ID
- CaltechAUTHORS:20170731-085900027
- NSF
- CCF-0728703
- NSF
- CCF-0829805
- NSF
- CCF-0832824
- NSF
- CCF-1317694
- NSF
- CCF-1117143
- NSF
- CCF-1618895
- Office of Naval Research (ONR)
- N00014-16-1-2139
- Gordon and Betty Moore Foundation
- NIH
- P50 GM081879
- Created
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2017-08-01Created from EPrint's datestamp field
- Updated
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2023-06-01Created from EPrint's last_modified field