Published May 2008
| Published
Journal Article
Open
Inverse temporal contributions of the dorsal hippocampus and medial prefrontal cortex to the expression of long-term fear memories
Chicago
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Abstract
Retrograde amnesia following disruptions of hippocampal function is often temporally graded, with recent memories being more impaired. Evidence supports the existence of one or more neocortical long-term memory storage/retrieval site(s). Neurotoxic lesions of the medial prefrontal cortex (mPFC) or the dorsal hippocampus (DH) were made 1 day or 200 days following trace fear conditioning. Recently encoded trace fear memories were most disrupted by DH lesions, while remotely encoded trace and contextual memories were most disrupted by mPFC lesions. These data strongly support the consolidation theory of hippocampus function and implicate the mPFC as a site of long-term memory storage/retrieval.
Additional Information
© 2008 Cold Spring Harbor Laboratory Press. Beginning 12 months from the full-issue publication date, articles published in Learning & Memory that are not designated as Open Access are distributed under the Creative Commons Attribution-Non-Commercial 4.0 International License (CC-BY-NC), as described at http://creativecommons.org/licenses/by-nc/4.0/. Received October 21, 2007; Accepted March 17, 2008. We thank C.J. Han, David Anderson, Barbara Knowlton, Frank Krasne, and David Jentsch for thoughtful discussion. This work was supported by NSF grant no. IBN9723295 to M.S.F., NIMH grant no. 5F31MH066549 to J.J.Q., and by a Discovery grant from the Gordon and Betty Moore Foundation. J.J.Q. is currently in the Department of Psychiatry, Yale University. Q.D.M. is currently in the School of Medicine at Western University. M.R.T. is currently at Roche Pharmaceuticals.Attached Files
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Additional details
- PMCID
- PMC3960031
- Eprint ID
- 79338
- Resolver ID
- CaltechAUTHORS:20170725-123811870
- NSF
- IBN-9723295
- NIH
- 5F31MH066549
- Gordon and Betty Moore Foundation
- Created
-
2017-07-25Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field
- Caltech groups
- Koch Laboratory (KLAB)