PIWIL4 Acts as a piRNA Binding, Epigenetically Active and Growth Regulatory Protein in Human Acute Myeloid Leukemia

Creators: Bamezai, S.; Mulaw, M.; Vegi, N.; Feuring-Buske, M.; Zhou, F.; Rohde, C.; Aravin, A.; Hoell, J.; Kloetgen, A.; Borkhardt, A.; Plass, C.; Müller-Tidow, C.; Rawat, V. P.; Buske, C.

Abstract

Piwi proteins are critically important for maintaining the self-renewing stem cell population in lower organisms through epigenetic silencing of transposable elements via DNA methylation and H3K9me3 marks, in close interaction with a novel class of non-coding RNA called piwi interacting RNA (piRNA).

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