Polymer-Based nanoparticle therapeutics

Abstract

We have translated three polymer-based nanoparticles into the clinic for use as cancer therapeutics. One of these nanoparticle, exptl. therapeutics was the first to show functional RNA interference (RNAi) in humans. At this time, these nanoparticles have been investigated in over 10 different clin. trials. I will describe how we translated these nanoparticles from the lab. at Caltech into clin., exptl. therapeutics. In addn. to investigations of polymer-based nanoparticle therapeutics for cancer, we are now concg. on developing polymer-based nanoparticles that cross the blood-brain-barrier. Our recent efforts will be presented.

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