Published October 2005
| public
Journal Article
Genomic Regulatory Networks and Animal Development
- Creators
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Stathopoulos, Angelike
- Levine, Michael
Abstract
The synthesis of gene expression data and cis-regulatory analysis permits the elucidation of genomic regulatory networks. These networks provide a direct visualization of the functional interconnections among the regulatory genes and signaling components leading to cell-specific patterns of gene activity. Complex developmental processes are thereby illuminated in ways not revealed by the conventional analysis of individual genes. In this review, we describe emerging networks in several different model systems, and compare them with the gene regulatory network that controls dorsoventral patterning of the Drosophila embryo.
Additional Information
© 2005 Elsevier Inc. Available online 3 October 2005. We are grateful to Robert Zinzen and Desirea Mecenas for providing pictures of embryos and sharing unpublished results. We also thank William Longabaugh and Dmitri Papatsenko for help with the circuit diagrams, and Eric Davidson, Anna Di Gregorio, and Paul Sternberg for helpful discussions. This work was funded by a grant from the NIH (GM46638) to M.L. and startup funds from Caltech to A.S.Additional details
- Eprint ID
- 76861
- DOI
- 10.1016/j.devcel.2005.09.005
- Resolver ID
- CaltechAUTHORS:20170424-130414231
- GM46638
- NIH
- Caltech
- Created
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2017-04-24Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field