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Published January 9, 2008 | Supplemental Material
Journal Article Open

Stepwise Self-Assembly of DNA Tile Lattices Using dsDNA Bridges

Abstract

The simple helical motif of double-strand DNA (dsDNA) has typically been judged to be uninteresting for assembly in DNA-based nanotechnology applications. In this letter, we demonstrate construction of superstructures consisting of heterogeneous DNA motifs using dsDNA in conjunction with more complex, cross-tile building blocks. Incorporation of dsDNA bridges in stepwise assembly processes can be used for controlling length and directionality of superstructures and is analogous to the "reprogramming" of sticky-ends displayed on the DNA tiles. Two distinct self-assembled DNA lattices, fixed-size nanoarrays, and extended 2D crystals of nanotracks with nanobridges, are constructed and visualized by high-resolution, liquid-phase atomic force microscopy.

Additional Information

© 2008 American Chemical Society. Received October 23, 2007. Publication Date (Web): December 12, 2007. This work has been supported by Grants CCF-0650083, BES-0609288, CCR-0326157, and EIA-0218376 from the National Science Foundation and Grant W911NF-05-1-0466 from the Army Research Office. We thank Prof. Jie Liu for providing access to a DI Veeco Nanoscope IIIa AFM.

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