Stepwise Self-Assembly of DNA Tile Lattices Using dsDNA Bridges
Abstract
The simple helical motif of double-strand DNA (dsDNA) has typically been judged to be uninteresting for assembly in DNA-based nanotechnology applications. In this letter, we demonstrate construction of superstructures consisting of heterogeneous DNA motifs using dsDNA in conjunction with more complex, cross-tile building blocks. Incorporation of dsDNA bridges in stepwise assembly processes can be used for controlling length and directionality of superstructures and is analogous to the "reprogramming" of sticky-ends displayed on the DNA tiles. Two distinct self-assembled DNA lattices, fixed-size nanoarrays, and extended 2D crystals of nanotracks with nanobridges, are constructed and visualized by high-resolution, liquid-phase atomic force microscopy.
Additional Information
© 2008 American Chemical Society. Received October 23, 2007. Publication Date (Web): December 12, 2007. This work has been supported by Grants CCF-0650083, BES-0609288, CCR-0326157, and EIA-0218376 from the National Science Foundation and Grant W911NF-05-1-0466 from the Army Research Office. We thank Prof. Jie Liu for providing access to a DI Veeco Nanoscope IIIa AFM.Attached Files
Supplemental Material - ja078122f-file002.pdf
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Additional details
- Eprint ID
- 76779
- Resolver ID
- CaltechAUTHORS:20170420-131101677
- CCF-0650083
- NSF
- BES-0609288
- NSF
- CCR-0326157
- NSF
- EIA-0218376
- NSF
- W911NF-05-1-0466
- Army Research Office (ARO)
- Created
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2017-04-20Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field