Distribution and localization of a G protein-coupled inwardly rectifying K⁺ channel in the rat
Abstract
The cellular distribution of the mRNA of the inwardly rectifying K^+ channel KGA (GIRK1) was investigated in rat tissue by in situ hybridization. KGA was originally cloned from the heart and represents the first G protein‐activated K^+ channel identified. It is expressed in peripheral tissue solely in the atrium, but not in the ventricle, skeletal muscle, lung and kidney. In the central nervous system KGA is most prominently expressed in the Ammon's horn and dentate gyrus of the hippocampus, neocortical layers II–VI, cerebellar granular layer, olfactory bulb, anterior pituitary, thalamic nuclei and several distinct nuclei of the lower brainstem. The abundant expression of KGA in many CNS neurons support its important role as a major target channel for G protein mediated receptor function.
Additional Information
© 1994 Federation of European Biochemical Societies. Manuscript received: 07 April 1994. Manuscript revised: 31 May 1994. We wish to thank Dr. Walter Stühmer for hisgenerous support. The study was supported in part by grants from the US National Institutes of Health (GM-29836, MH-49176), the US-Israel Binational Science Foundation, the Austrian Research Foundation and the Human Frontiers Organization.Additional details
- Alternative title
- Distribution and localization of a G protein-coupled inwardly rectifying K+ channel in the rat
- Alternative title
- Distribution and localization of a G protein-coupled inwardly rectifying K^+ channel in the rat
- Eprint ID
- 76393
- DOI
- 10.1016/0014-5793(94)00590-7
- Resolver ID
- CaltechAUTHORS:20170408-205029469
- GM-29836
- NIH
- MH-49176
- NIH
- Binational Science Foundation (USA-Israel)
- FWF Der Wissenschaftsfonds
- Human Frontier Science Program
- Created
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2018-03-30Created from EPrint's datestamp field
- Updated
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2023-09-28Created from EPrint's last_modified field