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Published June 2006 | public
Journal Article Metadata-only

Evidence for a Mitochondrial Regulatory Pathway Defined by Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α, Estrogen-Related Receptor-α, and Mitofusin 2

Soriano, Franscesc X.
Liesa, Marc
Bach, Daniel
Chan, David C. ORCID icon
Palaćin, Manuel
Zorzano, Antonio
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Abstract

Here, we report an increase in Mfn2 gene expression under conditions of high energy expenditure mediated by PGC-1α, and we also demonstrate that PGC-1α stimulates Mfn2 gene expression and that this is caused by two elements on the promoter that bind ERRα. In addition, we show that Mfn2 loss of function attenuates the effects of PGC-1α on mitochondrial membrane potential and that cold exposure causes an additional increase in PGC-1α in skeletal muscle from mice that are heterozygous knock-out (KO) for Mfn2.

Additional Information

© 2006 American Diabetes Association. Accepted February 21, 2006. Received April 22, 2005. This study was supported by research grants from the Ministerio de Ciencia y Tecnología (SAF 2005-00445), Grant 2005 SGR00947 from the Generalitat de Catalunya, the Fundació Marató de TV3 (300720), and the Instituto de Salud Carlos III RCMN (C03/08), RGDM (G03/212), and RGTO (G03/028). F.X.S. was the recipient of a predoctoral fellowship from the Instituto Danone and from the University of Barcelona, Barcelona, Spain. M.L. is the recipient of a predoctoral fellowship from the Ministerio de Educación y Cultura, Spain. We thank Tanya Yates for her editorial support, Dr. Diego Haro (University of Barcelona) for his scientific advice, and Drs. Luc Marti, Sara Pich, and Marta Camps for their help in animal studies. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

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August 19, 2023
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October 25, 2023