Model for the Interaction of T-cell Receptors with Peptide/MHC Complexes
- Creators
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Bjorkman, P. J.
- Davis, M. M.
Abstract
The immune response against a viral infection is mediated by two different types of cells known as B and T lymphocytes. The receptor on the B cell is the well-characterized antibody molecule, which exists in a membrane-bound form and in a secreted form involved in the initiation of complement-mediated killing and the inactivation of viral particles by direct binding. The recognition molecule on T cells is the membrane-bound T-cell antigen receptor, which has specificity for a combination of foreign antigen with a molecule of the major histocompatibility complex (MHC), as first demonstrated by Zinkernagel and Doherty (1974). MHC proteins exist in two closely related forms called class I and class II MHC molecules, both of which are cell-surface glycoproteins that are highly polymorphic in the human population. In general, class II MHC molecules are involved in interactions with T-helper cells, which cooperate with B cells to make antibody.
Additional Information
© 1989 Cold Spring Harbor Laboratory Press. The Authors acknowledge that six months after the full-issue publication date, the Article will be distributed under a Creative Commons CC-BY-NC License (Attribution-NonCommercial 4.0 International License, http://creativecommons.org/licenses/by-nc/4.0/).Attached Files
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Additional details
- Eprint ID
- 75800
- Resolver ID
- CaltechAUTHORS:20170406-103739638
- Created
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2017-04-06Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field