TCR Recognition and Selection In Vivo
Abstract
Much has been accomplished in identifying the molecules and genes responsible for T-cell recognition. We are now familiar with two distinct heterodimers, αβ and γδ, and we know that the former (at least) confers on a T cell the ability to recognize antigens complexed with specific molecules of the major histocompatibility complex (MHC) (Dembic et al. 1986; Saito and Germain 1987). Because of the recent solution of an MHC class I structure (Bjorkman et al. 1987a,b), its apparent generalization to class II molecules (Brown et al. 1988), as well as the similarity of T-cell receptor (TCR) primary sequences to immunoglobulins (Igs), we can guess a great deal about how they might interact (Chothia et al. 1988, Claverie et al. 1989; Davis and Bjorkman 1988; see also Bjorkman and Davis, this volume).
Additional Information
© 1989 Cold Spring Harbor Laboratory Press. The Authors acknowledge that six months after the full-issue publication date, the Article will be distributed under a Creative Commons CC-BY-NC License (Attribution-NonCommercial 4.0 International License, http://creativecommons.org/licenses/by-nc/4.0/). We wish to thank Dr. J. Bangs for advice concerning PtdIns-linked proteins, Angela Nervi for excellent technical assistance, and Brenda Robertson for preparation of the manuscript. We also thank National Institutes of Health for grant support. M.M.D. is a scholar of the Pew Foundation, L.J.B. is a fellow of the Leukemia Society of Anemia, and A.L. was previously a fellow of the Cancer Research Institute and is now supported by the Howard Hughes Medical Institute. B.F.de S.G. was supported by an Irvington House postdoctoral fellowship and is now supported by a fellowship from the Medical Research Council of Australia. P.J.B. was supported by an American Cancer Society postdoctoral fellowship, and J.F.E. is a centennial fellow of the Medical Research Council of Canada.Attached Files
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Additional details
- Eprint ID
- 75789
- Resolver ID
- CaltechAUTHORS:20170406-092457921
- NIH
- Pew Foundation
- Cancer Research Institute
- Howard Hughes Medical Institute (HHMI)
- Irvington House
- Medical Research Council (Australia)
- American Cancer Society
- Leukemia Society of America
- Medical Research Council of Canada
- Created
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2017-04-06Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field