Published February 27, 2004
| Supplemental Material
Journal Article
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A Mild and Efficient Synthesis of Oxindoles: Progress Towards the Synthesis of Welwitindolinone A Isonitrile
Chicago
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Abstract
The complete carbon skeleton of welwitindolinone A isonitrile has been prepared by using a [2+2] cycloaddition to establish the bicyclo[4.2.0]octane core and a SmI2-mediated intramolecular reductive cyclization between an enone and an aryl isocyanate to stereoselectively install the spiro-oxindole (see scheme; DBU=1,8-diazabicyclo[5.4.0]undec-7-ene).
Additional Information
© 2004 WILEY-VCH Verlag GmbH & Co. Issue online: 25 Feb 2004. Version of Record online: 11 Feb 2004. Manuscript Received: 10 Nov 2003. We gratefully acknowledge financial support from Yamanouchi, Merck, Pfizer, and Amgen. J.M.R. is the recipient of an NIH postdoctoral fellowship. K.R. thanks Sankyo Co., LTD.; M.H. thanks Daiso Co., LTD., M.M.W. thanks Bristol Myers Squibb for a graduate fellowship.Attached Files
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Additional details
- Eprint ID
- 75662
- DOI
- 10.1002/anie.200353282
- Resolver ID
- CaltechAUTHORS:20170404-071621138
- Yamanouchi
- Merck
- Pfizer
- Amgen
- Bristol-Myers Squibb
- NIH Postdoctoral Fellowship
- Sankyo Co., Ltd.
- Daiso Co., Ltd.
- Created
-
2017-04-04Created from EPrint's datestamp field
- Updated
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2021-11-15Created from EPrint's last_modified field