Published 2006
| public
Book Section - Chapter
Structural Insights into Antibody-Mediated Mucosal Immunity
- Creators
- Hamburger, A. E.
-
Bjorkman, P. J.
- Herr, A. B.
- Others:
- Honjo, Tasuku
- Melchers, Fritz
Abstract
The mucosal regions of the body are responsible for defense against environmental pathogens. Particularly in the lumen of the gut, antibody-mediated immune responses are critical for preventing invasion by pathogens. In this chapter, we review structural studies that have illuminated various aspects of mucosal immunity. Crystal structures of IgA1-Fc and IgA-binding fragments of the polymeric immunoglobulin receptor and FcαRI, combined with models of intact IgA and IgM from solution scattering studies, reveal potential mechanisms for immune exclusion and induction of inflammatory responses. Other recent structures yield insights into bacterial mechanisms for evasion of the host immune response.
Additional Information
© 2006 Springer Berlin Heidelberg. The authors would like to thank Dr. Steve Perkins (University College London) for providing the coordinates of pentameric IgM.Additional details
- Eprint ID
- 75509
- DOI
- 10.1007/3-540-30657-9_8
- Resolver ID
- CaltechAUTHORS:20170329-110607686
- Created
-
2017-03-29Created from EPrint's datestamp field
- Updated
-
2021-11-15Created from EPrint's last_modified field
- Series Name
- Current Topics in Microbiology and Immunology
- Series Volume or Issue Number
- 308