Published November 1995
| Published
Journal Article
Open
The influence of boundary conditions on the accuracy of diffusion theory in time-resolved reflectance spectroscopy of biological tissues
Chicago
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Abstract
The applicability of diffusion theory for the determination of tissue optical properties from time-resolved reflectance spectroscopy is investigated. Analytical expressions from diffusion theory using the three most commonly assumed boundary conditions at the air-tissue interface are compared with time-resolved Monte Carlo simulations and measurements on tissue phantoms. The effects of the choice of the boundary conditions on the accuracy of the findings for the optical parameters are quantified, and criteria for accurate curve-fitting algorithms are developed.
Additional Information
© 1995 IOP Publishing Ltd. Received 30 January 1995, in final form 30 June 1995. The authors would like to thank Dr H Liu and Professor B Chance from the Department of Biochemistry and Biophysics at the University of Pennsylvania for support in the experimental set-up and the careful review of the paper. Furthermore the help of D Boas with the calculation of the scattering coefficient of the polystyrene sphere solutions is appreciated. This work was supported by the Robert A Welch Foundation, the Department of Energy, and NIH (R29-HL45045).Attached Files
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Additional details
- Eprint ID
- 75074
- Resolver ID
- CaltechAUTHORS:20170313-150303167
- Robert A. Welch Foundation
- Department of Energy (DOE)
- NIH
- R29-HL45045
- Created
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2017-03-13Created from EPrint's datestamp field
- Updated
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2022-07-12Created from EPrint's last_modified field