Active Conservation of Noncoding Sequences Revealed by Three-Way Species Comparisons

Creators: Dubchak, Inna; Brudno, Michael; Loots, Gabriela G.; Pachter, Lior; Mayor, Chris; Rubin, Edward M.; Frazer, Kelly A.

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Abstract

Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human–mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time. [The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AF276990.]

Additional Information

© 2000 Cold Spring Harbor Laboratory Press. The Authors acknowledge that six months after the full-issue publication date, the Article will be distributed under a Creative Commons CC-BY-NC License (Attribution-NonCommercial 4.0 International License, http://creativecommons.org/licenses/by-nc/4.0/). Received March 28, 2000. Accepted July 12, 2000. We thank Keith Lewis, Willow Dean, and Cathy Blankespoor for DNA sequencing and Nila Patil for valuable remarks on the manuscript. This work was supported by the following grants: U.S. Department of Energy contract DE-AC376SF00098 and NIH GM-5748202 (K.A.F.) The publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

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