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Published December 1987 | public
Journal Article

Flow effects on the viability and lysis of suspended mammalian cells

Abstract

A mouse myeloma cell line growing in suspension was subjected intermittently to flow through a sudden contraction and turbulent flow in a capillary tube. The probability of lysis per pass through the capillary tube increased with average wall shear stress level and with residence time per pass in the tube. Lysis was first observed at a threshold average wall shear stress level of 1800 dyn/cm^2. Although the flow caused lysis, it had no effect on cell viability.

Additional Information

© 1987 Science and Technology Letters. First Online: 01 December 1987.

Additional details

Created:
August 19, 2023
Modified:
October 24, 2023