Published September 6, 2006
| Supplemental Material
Journal Article
Open
Catalytic Enantioselective Decarboxylative Protonation
Abstract
We report a highly enantioselective, general catalytic system for the facile synthesis of tertiary stereocenters by protonation adjacent to cyclic ketones. The method relies on catalytic decarboxylative protonation of readily accessible racemic quaternary β-ketoesters. A range of substituted cycloalkanone compounds can be accessed through this process with high levels of enantioselectivity.
Additional Information
© 2006 American Chemical Society. Received 17 May 2006. Published online 15 August 2006. Published in print 1 September 2006. The authors thank Eli Lilly (predoctoral fellowship to J.T.M.), Sankyo Co., Ltd. (financial support of T.N.), The Fannie and John Hertz Foundation (predoctoral fellowship to D.C.B.), Merck, Amgen, Johnson & Johnson, Bristol-Myers Squibb, and the Dreyfus Foundation for generous funding.Attached Files
Supplemental Material - ja063335asi20060711_012626.pdf
Files
ja063335asi20060711_012626.pdf
Files
(569.4 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:05d2e292ae9b390e3e2c85008f533f2e
|
569.4 kB | Preview Download |
Additional details
- Eprint ID
- 74447
- Resolver ID
- CaltechAUTHORS:20170222-073849342
- Sankyo Co., Ltd.
- Fannie and John Hertz Foundation
- Merck
- Amgen
- Johnson and Johnson
- Bristol-Myers Squibb
- Camille and Henry Dreyfus Foundation
- Created
-
2017-02-22Created from EPrint's datestamp field
- Updated
-
2021-11-11Created from EPrint's last_modified field