Published December 2002
| public
Journal Article
T-lineage specification and commitment: a gene regulation perspective
- Creators
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Rothenberg, Ellen V.
Abstract
T lymphocytes originate from pluripotent precursors and undergo lasting commitment to the T cell developmental fate during their processing in the thymus. Commitment includes both the acquisition of essential T cell characteristics and the foreclosing of other developmental options. Gain of T cell characteristics is probably mediated by separate mechanisms, at least in detail, from loss of alternative developmental potentials. Programmed shifts in survival requirements make changes irreversible. Here we review the current evidence identifying the regulatory components of this commitment pathway, and the first hints of how they work together. Roles for PU.1, GATA-3, and their target genes are highlighted.
Additional Information
© 2002 Elsevier Science Ltd. Published December 2002; available online 21 November 2002. I apologize to many colleagues whose research could not be cited properly due to space limitations, and I thank Michele K. Anderson, Rochelle A. Diamond, Gabriela Hernandez-Hoyos, Janice C. Telfer, and Hua Wang for the opportunity to cite results of their work in my laboratory prior to publication. Funding for the research discussed in this review was from the National Institutes of Health/National Cancer Institute (CA90233), from the National Science Foundation (MCB-9983129), from the Caltech DNA Sequencer Royalty Fund, and initially from the Stowers Institute for Medical Research.Additional details
- Eprint ID
- 74093
- Resolver ID
- CaltechAUTHORS:20170206-141657037
- CA90233
- NIH
- MCB-9983129
- NSF
- DNA Sequencer Royalty Fund, Caltech
- Stowers Institute for Medical Research
- Created
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2017-02-06Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field