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Published April 1990 | public
Journal Article

Death and transfiguration of cortical thymocytes: a reconsideration

Abstract

The fate of most cells in the mammalian thymus, namely CD4^+CD8^+ (double positive) cortical cells, is unknown. A fraction of the cells in this population serve as developmental intermediates, but the vast majority will die. In this article Ellen Rothenberg discusses how and when the cells are condemned or promoted to maturity, in the light of intriguing new data that suggests that they may be able to be rescued for longer than was previously thought.

Additional Information

© 1990 Published by Elsevier Ltd. Work in the author's laboratory was supported by grants from the USPHS-National Institutes of Health (Al 19752 and CA 39605), the Lucille B Markey Charitable Trust and the University of California University-Wide Task Force on AIDS. I am very grateful to Anthony Shields for bringing his findings to my attention, to Cynthia Guidos. Rochelle Diamond and Paul Boyer for their critical reading of this manuscript, to Cherrie Leighton for helping to prepare it for submission, and to Roland Scollay, Eric Jenkinson and John Owen for exceptionally stimulating and thought-provoking discussion of these issues.

Additional details

Created:
August 19, 2023
Modified:
October 24, 2023