Non-coding RNAs in Transcriptional Regulation
- Creators
- Chen, Yung-Chia Ariel
- Aravin, Alexei A.
Abstract
Transcriptional gene silencing guided by small RNAs is a process conserved from protozoa to mammals. Small RNAs loaded into Argonaute family proteins direct repressive histone modifications or DNA cytosine methylation to homologous regions of the genome. Small RNA-mediated transcriptional silencing is required for many biological processes, including repression of transposable elements, maintaining the genome stability/integrity, and epigenetic inheritance of gene expression. Here, we will summarize the current knowledge about small RNA biogenesis and mechanisms of transcriptional regulation in plants, Drosophila, Caenorhabditis elegans, and mice. Furthermore, a rapidly growing number of long non-coding RNAs (lncRNAs) have been implicated as important players in transcription regulation. We will discuss current models for long non-coding RNA-mediated gene regulation.
Additional Information
© 2015 Springer International Publishing AG. Published online: 17 February 2015. We thank members of the Aravin lab and particularly Alexandre Webster for discussion and comments. The work in Aravin laboratory is supported by grants from the National Institutes of Health (R01 GM097363 and DP2 OD007371A) and by the Damon Runyon-Rachleff, the Searle Scholar, and the Packard Fellowship Awards to A.A.A. Compliance with Ethics Guidelines. Yung-Chia Ariel Chen and Alexei A. Aravin declare that they have no conflict of interest. Human and Animal Rights and Informed Consent: This article does not contain any studies with human or animal subjects performed by any of the authors.Attached Files
Accepted Version - nihms664932.pdf
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Additional details
- PMCID
- PMC4479201
- Eprint ID
- 73234
- Resolver ID
- CaltechAUTHORS:20170104-154530088
- R01 GM097363
- NIH
- DP2 OD007371A
- NIH
- Damon Runyon Cancer Research Foundation
- Searle Scholars Program
- David and Lucile Packard Foundation
- Created
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2017-01-04Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field