Published December 14, 2016
| Supplemental Material
Journal Article
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Single-step synthesis of 3-hydroxycarbazoles by annulation of electron-rich anilines and quinones
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Abstract
A single-step synthesis of 3-hydroxycarbazoles has been achieved via annulation of electron-rich anilines and quinones in PhMe/AcOH (4:1) at room temperature. This chemistry tolerates various substituted benzoquinones and naphthoquinones, however, is sensitive to both the electronic and steric properties of the anilines. The desired 3-hydroxycarbazole derivatives are generally produced in moderate yield.
Additional Information
© 2016 Elsevier. Received 18 October 2016; accepted 2 November 2016; available online 4 November 2016. We thank Dr. Francis Gosselin (Genentech, Inc.) for helpful discussion and reviewing the manuscript.Attached Files
Supplemental Material - mmc1.docx
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Additional details
- Eprint ID
- 73187
- DOI
- 10.1016/j.tetlet.2016.11.009
- Resolver ID
- CaltechAUTHORS:20170103-154034263
- Created
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2017-01-04Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field