Published January 9, 2018
| Published + Supplemental Material + Submitted
Journal Article
Open
Mapping the microscale origins of magnetic resonance image contrast with subcellular diamond magnetometry
Abstract
Magnetic resonance imaging (MRI) is a widely used biomedical imaging modality that derives much of its contrast from microscale magnetic field gradients in biological tissues. However, the connection between these sub-voxel field patterns and MRI contrast has not been studied experimentally. Here, we describe a new method to map subcellular magnetic fields in mammalian cells and tissues using nitrogen vacancy diamond magnetometry and connect these maps to voxel-scale MRI contrast, providing insights for in vivo imaging and contrast agent design.
Additional Information
© 2018 The Authors. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Received: 15 April 2017. Accepted: 03 December 2017. Published online: 09 January 2018. We acknowledge Arnab Mukherjee, George Lu, Vivek Bharadwaj, My Linh Pham, Andrei Faraon, Geoffrey Blake, Joe Kirschvink, Manuel Monge, Hans Gruber, Michael Tyszka, Russ Jacobs, and John Wood for helpful discussions. This work was supported by the National Science Foundation Graduate Research Fellowship (P.R.), Caltech Center for Environmental–Microbial Interactions (M.G.S.), the Burroughs Wellcome Fund (M.G.S.), the NSF EPMD and PoLS programs (R.L.W.), and the U. S. Army Research Laboratory and the U. S. Army Research Office under contract/grant number W911NF1510548 (R.L.W.). Research in the Shapiro Laboratory is also supported by the Heritage Medical Research Institute, the Pew Scholarship in the Biomedical Sciences and the David and Lucile Packard Fellowship for Science and Engineering. Hunter C. Davis and Pradeep Ramesh contributed equally to this work. Author Contributions: H.C.D., P.R. and M.G.S. conceived and planned the study with input from J.F.B., D.R.G. and R.L.W. H.C.D., P.R. and J.F.B. constructed the magneto-microscope. H.C.D. performed the NV magnetometry experiments and analyzed the resulting data. H.C.D., P.R. and A.L.-G. prepared the in vitro and in vivo specimens. P.R. and H.C.D. performed the MRI measurements and analyzed the resulting data. H.C.D. and A.B. developed and performed the Monte Carlo simulations. H.C.D., P.R. and M.G.S. wrote the manuscript with input from all other authors. Code availability: All the relevant software scripts are available from the authors upon request. Data availability: All the relevant data are available from the authors upon request. The authors declare no competing financial interests.Attached Files
Published - s41467-017-02471-7.pdf
Submitted - 1610.01924.pdf
Supplemental Material - 41467_2017_2471_MOESM1_ESM.pdf
Supplemental Material - 41467_2017_2471_MOESM2_ESM.pdf
Files
41467_2017_2471_MOESM1_ESM.pdf
Additional details
- Alternative title
- Mapping the Microscale Origins of MRI Contrast with Subcellular NV Diamond Magnetometry
- PMCID
- PMC5760582
- Eprint ID
- 72547
- Resolver ID
- CaltechAUTHORS:20161205-095517669
- NSF Graduate Research Fellowship
- Caltech Center for Environmental Microbial Interactions (CEMI)
- Burroughs Wellcome Fund
- NSF
- Army Research Office (ARO)
- Heritage Medical Research Institute
- Created
-
2016-12-06Created from EPrint's datestamp field
- Updated
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2022-03-18Created from EPrint's last_modified field
- Caltech groups
- Heritage Medical Research Institute, Caltech Center for Environmental Microbial Interactions (CEMI), Rosen Bioengineering Center