Published February 16, 2012
| Accepted Version
Journal Article
Open
Modular regulatory principles of large non-coding RNAs
- Creators
- Guttman, Mitchell
- Rinn, John L.
Abstract
It is clear that RNA has a diverse set of functions and is more than just a messenger between gene and protein. The mammalian genome is extensively transcribed, giving rise to thousands of non-coding transcripts. Whether all of these transcripts are functional is debated, but it is evident that there are many functional large non-coding RNAs (ncRNAs). Recent studies have begun to explore the functional diversity and mechanistic role of these large ncRNAs. Here we synthesize these studies to provide an emerging model whereby large ncRNAs might achieve regulatory specificity through modularity, assembling diverse combinations of proteins and possibly RNA and DNA interactions.
Additional Information
© 2012 Macmillan Publishers Limited. Published online 15 February 2012. We thank M. Cabili, J. Engreitz, M. Garber, P. McDonel and A. Pauli for their reading and suggestions; T. Cech for comments and suggestions; E. Lander for helpful discussions and ideas; and S. Knemeyer and L. Gaffney for assistance with figures in this Review.Attached Files
Accepted Version - nihms631736.pdf
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Additional details
- PMCID
- PMC4197003
- Eprint ID
- 72230
- Resolver ID
- CaltechAUTHORS:20161122-073117519
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2016-11-22Created from EPrint's datestamp field
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2021-11-11Created from EPrint's last_modified field