Published February 10, 2005
| Published
Journal Article
Open
Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography
Abstract
Green laser pulses at a wavelength of 532 nm from a Q-switched Nd:YAG laser were employed as irradiation sources for photoacoustic tomography (PAT). The vascular structure of the brain was imaged clearly, with optimal contrast, because blood has strong absorption near this wavelength. The photoacoustic images of rat brain tumors in this study clearly reveal the angiogenesis that is associated with tumors. Brain tumors can be identified based on the distorted vascular architecture of brain tumorigenesis and related vascular changes, such as hemorrhage. This research demonstrates that PAT can potentially provide a powerful tool for small-animal biological research.
Additional Information
© 2005 Optical Society of America. Received 19 July 2004; revised manuscript received 7 October 2004; accepted 20 October 2004. This study is sponsored by the National Institutes of Health (grants R01 NS46214-01 and R01 EB000712).Attached Files
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Additional details
- Eprint ID
- 72168
- Resolver ID
- CaltechAUTHORS:20161118-132318724
- R01 NS46214-01
- NIH
- R01 EB000712
- NIH
- Created
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2016-11-18Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field